DNA polymerases are the enzymes that build DNA in cells. During DNA replication (copying), most DNA polymerases can “check their work” with each base that they add. This process is called proofreading.

The term proofreading is used in genetics to refer to the error-correcting processes, first proposed by John Hopfield [1] and Jacques Ninio, [2] involved in DNA replication, immune system specificity, and …

Most of the mistakes during DNA replication are promptly corrected by DNA polymerase by proofreading the base that has just been added (Figure 1). In proofreading, the DNA pol reads the newly added …

Dec 27, 2023 · DNA polymerase (DNAP) can correct errors in DNA during replication by proofreading, a process critical for cell viability.

Most of the mistakes during DNA replication are promptly corrected by DNA polymerase by proofreading the base that has been just added (Figure 1). In proofreading, the DNA pol reads the newly added …

Jun 9, 2025 · Proofreading is a critical component of the DNA replication process, enabling the correction of errors and maintaining the integrity of the genome. The proofreading function is …

A 3´→ 5´ proofreading exonuclease domain is intrinsic to most DNA polymerases. It allows the enzyme to check each nucleotide during DNA synthesis and excise mismatched nucleotides in the 3´ to 5´ …

Dec 27, 2023 · Here, we present an ensemble of nine high-resolution structures representing human mitochondrial DNA polymerase Gamma, Polγ, captured during consecutive proofreading steps.

During DNA replication, an enzyme called DNA polymerase proofreads the genetic code of DNA.

DNA proofreading is a critical process that ensures replication accuracy by correcting errors in nucleotide pairing. It primarily relies on the activities of DNA polymerase and exonuclease during and …